Replies to post #508533 on NorthWest Biotherapeutics Inc (NWBO)

[Lykiri]

DL7,
thank you for sharing the story of your mother.
I'm happy she did very well from her diagnosis at the end of 2011 until about 2017.
Your mom was probably one of the early patients (n=38)enrolled between July 2007 and May 2012 with an unknown MGMT gene promoter.
Data 2017:

The MGMT gene promoter was methylated in 39.6% of patients (n?=?131) and unmethylated in 48.9% (n?=?162), with information not available for 11.5% (n?=?38; the missing data relates to the early patients enrolled a decade ago).

I assume 26 DCVax-L patients and 12 placebo patients. (26+12=38)
They reduced the number of unidentified MGMT by further testing/processes to identify.
Data 2022:

Missing MGMT gene promoter data = 11 DCVax-L patients.
1 “Unknown” DCVax-L patient alive 36 months from randomization.

They found the missing data related to 15 early DCVax-L patients enrolled between July 2007 and May 2012 and it’s interesting that the MGMT gene promotor is unmethylated for all those patients. IMO.