Given that the SOC is so pitifully low for AD that doesn't seem like a very high bar.
The Primary endpoints are reduction in decline, not even stopping the decline. So reducing the rate of decline would be a successful trial outcome. Would that be be blowing the SOC out of the water?
Blowing SOC out of the water on topline data, no ifs, buts, changes of endpoints, subgroup help, OLE help etc.