"Will there be another opportunity to take substantial $AVXL profit and live with the potential that an even bigger, not return percentage, but absolute return could have been had?"
I believe even if someone got in at $10+, the AD trial fails and we go back to low single-digits, there may be an opportunity to break even with Rett. But if Rett fails, it will be the greatest lesson in my 15-year biotech-investing experience.