Definitely over my head, but biomarkers and each patient being their own control is definitely intriguing.
(In one breath) It would make sense, if I'm understanding correctly, that if there is a meta database that can calibrate the median survival of GBM patients by their biomarkers, with some confidence level, such that it qualifies as a control group, then each DCVax-L trial patient, based on their biomarkers, their actual survival months can then be measured for efficacy against this control group, i.e. each patient as a control. All this is supplementary information of course because there is not an official endpoint in the trial for this.