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j e d

05/11/22 9:50 PM

#471600 RE: dmb2 #471576

Thank you, this could be the case. This would imply that, to match the chart for Overall Survival in Newly Diagnosed GBM:

At 0 months: 1366 patients in ECA database, 1366 at risk (100%)
At 12 months: 1366 patients in ECA database, 888 at risk (65%)
At 24 months: 987 patients in ECA database, 306 at risk (31%)
At 36 months: 400 patients in ECA database, 62 at risk (15.5%)
At 48 months: 71 patients in ECA database, 7 at risk (9.9%)
At 60 months: 0 at risk? Not sure how 5.7% would be derived

Is this what you mean? I hit a snag at 60 months with a DIV0 error--there's likely something else I'm missing. But this scenario would make sense as not all trial databases followed patients for as long as NWBO did and so more data is available for the earlier months.