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Jasbg

04/14/22 5:58 PM

#374891 RE: Birdbrain Ideas #374890

BBI, Thanks for you answer here. After a little thought I decides to delete the post about Lovaza - as the data is rather thin' - when you dig a little - regarding Alzheimer's. Actually not about Lovaza (not mentioned anywhere) but about OTC Fish Oil general in the Article from the AZ site.

https://www.alzheimers.org.uk/about-dementia/risk-factors-and-prevention/omega-3-and-dementia
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I changed to a general question to the doctors in this forum - what drug they would use/recommend if someone in their close family got Alzheimers.

Exited to see if anyone have an opinion/advice around this big question !

Thanks in advance :)

Jasbg

PS a lot of informations on the AZ site - for whom this might relevant:

https://www.alzheimers.org.uk/
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Number sleven

04/14/22 6:51 PM

#374892 RE: Birdbrain Ideas #374890

BBI,
https://www.clinicaltrials.gov/ct2/show/NCT02719327?term=Vascepa&draw=2&rank=9
The BRAVE study should read out with positive results. Prior studies have shown that Icosapent ethyl had statistically significant effects on both the primary and secondary endpoints in BRAVE. This study is fairly invasive. Each patient will need to undergo 3 separate spinal taps.(unless there is another way to collect CSF.) The study also has a data monitoring committee. I would think that the committee would have halted the study if the data collected, to this point, wasn't positive. I don't know if this study would be enough to apply for an SNDA. FDA did recently lower the bar for Alzheimer's disease approvals.
Sleven,
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Jasbg

04/15/22 6:13 AM

#374906 RE: Birdbrain Ideas #374890

BBI, As you say - this is probably the most sufferings area of 'fighting decease' out there. Still researchers is in realty 'guessing' what will help/prevent the terrible decease.

But a lot of research is going on. An overview of where things stand right now can be found in link below:

https://www.alzheimers.org.uk/research/our-research/research-projects/current-projects