Feb 21, 2013 Preclinical studies in non-human primates already generated extremely promising data demonstrating 100% protection against multiple intra-vaginal challenges with a live virus."
Providing Mymetics obtains additional sources of financing for this project, the company plans to test its prophylactic HIV-1 vaccine candidate in a combined Phase I and II trial to investigate an additional HIV-1 antigen and a further optimized vaccine formulation.
Delivery can be achieved by contacting the dendritic cells with a virosome ex vivo, whereupon the infected dendritic cells are provided to the patient. At other times, delivery may be achieved by delivering the virus to the subject in order to infect dendritic cells in vivo. The dendritic cells then stimulate antigen-specific T cells or B cells in the patient to induce cellular and humoral immune responses to the expressed antigen. In this manner, a patient suffering from a disease or disorder is treated by generating immune cells with the desired specificity.