flipper44,
Yep or just L and Direct or just Direct with proper spacing to maintain proper signaling which is the normal way immune response prevents early checkpoint interference in pretty much all diseases. Checkpoint response is designed to bring immune response to an end when the victory has been won. When properly activated and matured DCs move off site due to hypoxia (low oxygen for those not familiar) the proper signaling in the tumor environment is lost. New uneducated (en vivo) DCs follow the lead of the others when that happens as the tumor environment reverts back and the checkpoints step in and begin the process of shutting down the response instead of properly activating the new, constantly provided from various sources in self(en vivo), DCs. NWBO has nailed this understanding down to a whole new level. What you describe is pointing to the best interim option starting with brain cancer specifically. Best wishes.
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