Replies to post #145856 on NanoViricides Inc (NNVC)

[KMBJN]

I don't know if I'm scientifically literate enough to answer the question or not, but I can give my impressions.

To answer your question,

If the RDV concentration and dosages in the NV-CoV-2 injections was higher than RDV only injections, couldn't that be the determining factor in the survival? More RDV is the cause for the increased survival?

The NV-CoV-2 contains NO RDV, and it works better than RDV. Figure 4 from the rat lethal CoV infection model is what I showed, and here is the caption:

Figure 4:

Survival of NV-CoV-2 (Polymer) treated or untreated Rats infected with NL63 virus The untreated rats and the Vehicle-treated rats infected with the Cov-NL63 virus survived until Day 5. Rats treated daily with Remdesivir only, 10 mg/kg, survived 7.5 days. The rats treated with NV-CoV-2, 160 and 320 mg/kg, survived until Days 13.5 and 14, respectively (4A). Further the survival of the infected rats were dependent on the number of days and dosage of the drug, NV-CoV-2 polymer (4B).

So, it looks like the drug works, yes, to prolong survival in an animal model of acute CoV disease? or are these authors all making things up?


Some of the doses from the rat in vivo PK paper are for NV-CoV-2-R, not the amount of RDV encapsulated in NV-CoV-2-R. NV-CoV-2-R consists of NV-CoV-2 plus whatever amount of RDV is encapsulated inside.

The rat in vivo PK preprint figures all use plasma RDV divided by total RDV in the dose given in order to be able to compare the raw vs. NV-CoV-2-R encapsulated form.

RDV values in male rats plasma obtained (mg/mL) after 1st. and 5th injection of the drugs were normalized by dividing with the amount of RDV administered (mg/kg of rat body weight) and shown in Fig. 2 and Fig. 3.

So the plasma levels are for equivalent amount of RDV given as "raw" RDV (well combined with their SBECD) or RDV inside NV-CoV-2.


One potentially troubling note about the dosing ... I thought the doses given in general were pretty high. Medium dose is 160 mg/kg for rat /6.2 to convert to human equivalent = ~25 mg/kg, or for 60 kg patient that is 1.3 g. If it takes a while to make kg scale batches, that isn't very many doses, even if some of that 1.3 g is composed of remdesivir.