Replies to post #424246 on NorthWest Biotherapeutics Inc (NWBO)

[biosectinvestor]

Hi Senti,

I do not know about the Fife part, but your view on the likely approach on the trial’s synthetic placebo arm is consistent with what I think would make the most sense from a regulator’s perspective. I can’t claim I know, but I do not think the back of the envelope, down and dirty comparisons between specific trials makes sense. A larger placebo group, reflecting similarities in actual treatment and outcomes seems more likely to be the best option statistically.

Some may obviously disagree, which is fine. But I think that is, in the long-run, where we are headed as they start to focus on data.

[sukus]

It started to make sense for me why WHO recently redefined the GBM definition. I believe if this is true, this to be the critical starting place before constructing the bigger comparable control group like what you referred to. I feel the pieces fall into places nicely if this is true. Wow wow wow. Thanks Senti.

Btw Senti, I am so happy if we can eliminate K-M curve. I don't like it, this K-M Curve is a toy that can be easily manipulated.