What I've seen in all cases that I checked (4 or 5ish) w Project Orbis is that BTD was given to the drug prior to approval. So that's a sign I look for. I haven't been following RMAT approvals but wondering if that's the case also but I don't know. However, I would expect expectations to go sky high on the RMAT pathway once we get good TLD/Journal article. Then the cat will be out of the bag for all these accelerated pathways.