I suppose what you are suggesting is that IDH mutation is to be used as a screen upon the data rather than a piece of the data within the database. Filter out the patients as though it were performed before randomization and remove from both groups. If the originally randomized group did not separate statistically eventually over time, which I believe they have, then to remove the skew would kick it over the top for sure and be worthy of delay.
I am not so certain that could happen after lock, but I am also not certain that it cannot. I hadn’t considered that possibility. I just assumed it would be in a multivariate analysis. Interesting theory though to ponder as it would be worth the insurance that it provides. How does one obtain a clean reference database of contemporary trials? Is that what is taking so long? I can’t even fathom that.
I still think we see data soon and only three trading days until SNO release of LBAs…hard to believe
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