"Take calculated risks. That is quite different from being rash." George S. Patton
That applies to investing as well as battle plans.
AVXL is a calculated risk, with the risk/reward scales continuing to tip to the reward side with every new release of trial data.
(Patton was a the greatest warrior during WW2. My late father in law and great uncle fought with him during the invasion of Sicily and then on into France. They loved and admired him.)