The terms "effective amount" or "therapeutically effective amount" as used herein, is to be broadly understood to encompass both a sufficient amount of at least one agent being administered which achieve a desired result, e.g., to relieve to some extent one or more symptoms of a disease or condition being treated as well as a to prevent the occurrence of one or more symptoms of a disease or condition being treated (a prophylactically effective amount). In certain instances, the result is a reduction and/or alleviation of the signs, symptoms, or causes of a disease, or any other desired alteration of a biological system. In certain instances, an "effective amount" for therapeutic uses is the amount of the composition comprising an agent as set forth herein required to provide a clinically significant decrease in a disease. An appropriate "effective" amount in any individual case is determined using any suitable technique, such as a dose escalation study. The term "prophylactic" or "prophylaxis" shall mean preventing or reducing the likelihood that a disease, condition or event will occur. A treatment will be considered therapeutically prophylactic if a subject is asymptomatic for at least about 30 days or if there is a reduction in episodes of at least about 50% over a 30 day period as compared with pre-treatment rate of occurrence.