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Dr Bala

05/03/21 1:42 PM

#374149 RE: exwannabe #374146

Nonsensical post. Razzmatazz.
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CaptainObvious

05/03/21 1:46 PM

#374153 RE: exwannabe #374146

I wonder if there is enough information in SOC trials to sort out the same DCVax trial criteria, so as to compare apples to apples.
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hope4patients

05/03/21 2:03 PM

#374163 RE: exwannabe #374146

This post is absolutely false. Over 300 of the screened patients did NOT even have GBM! See slides 11 & 16
https://nwbio.com/wp-content/uploads/Boston-Presentation-v0.2.pdf

Also the patient demographics are comparable to other GBM trials, especially w/ respect to known prognostic factors. 75% of the patients are over 50 and more of the patients are unmethylated.

The trial excluded early progressives and pseudoprogressors JUST LIKE the following recent trials:
Stupp et al. 2015, 2017
Weller et al. 2017
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survivor1x

05/07/21 12:28 AM

#375086 RE: exwannabe #374146

ICT 107 exclusion

Exclusion Criteria:

Recurrent disease
Radiosurgery including Gamma Knife, linear accelerator based radiosurgery, CyberKnife and placement of Gliadel wafer
Presence of any other active malignancy or prior history of malignancy (except for basal cell carcinoma of the skin)
Severe pulmonary, cardiac or other systemic disease
Congestive heart failure Class III or IV according to New York Heart Association (NYHA)
Presence of an acute infection requiring active treatment with antibiotics/antivirals; prophylactic administration is allowed
Known history of an autoimmune disorder
Known human immunodeficiency virus (HIV) positivity or acquired immunodeficiency syndrome (AIDS) related illness or other serious medical illness
Breastfeeding
Received any other therapeutic investigational agent within 30 days of enrollment
Reduction of steroids (dexamethasone) to a maximum of 2 mg twice a day (BID) prior to the first administration of study vaccine
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survivor1x

05/07/21 12:43 AM

#375088 RE: exwannabe #374146

Explain why the worst are doing the best. Why such a huge delta on Mesenchymal if DCVAX isn't working. Probably the same reason why checkpoints work with more mutated cancers.


Fine we will take all patients that express a Mesenchymal subtype 50% and cure 70% of them. And I am sure LL knows how to cause a Mesenchymal transition so we just might have a method of creating more long term survivors.

https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-021-01151-4

https://academic.oup.com/brain/article/142/4/847/5420896