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rule_rationale

03/10/21 10:52 PM

#351670 RE: Lemoncat #351668

At least use equivalent cell lines please.

Literature numbers below.

Brilacidin:
426 (CC50 = 241 µM/IC50 = 0.565 µM), Calu-3 Cells [1]

Rem:
38 (CC50 = 50 µM/IC50 = 1.3 µM), Calu-3 Cells [2]


[1] Bakovic, A.; Risner, K.;
Bhalla, N.; Alem, F.; Chang, T.L.;
Weston, W.K.; Harness, J.A.;
Narayanan, A. Brilacidin
Demonstrates Inhibition of
SARS-CoV-2 in Cell Culture. Viruses
2021, 13, 271. https://doi.org/
10.3390/v13020271

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436731/#!po=47.7778

steelyeye

03/10/21 10:58 PM

#351671 RE: Lemoncat #351668

A nice summary of important factors


https://investorshub.advfn.com/boards/read_msg.aspx?message_id=162382777

I wouldn't stress over the selectivity index too much.



Did the FDA grant Fast Track Status to B for C-19 because they were stressed (positively) over the selectivity index?