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jammyjames

01/05/21 4:15 PM

#345087 RE: flipper44 #345052

"No, but when you are conducting a seminal trial, a blinded trial prevents the dangerous benefits of excessive manipulative (real-time) censoring."

yes ofcourse...that's clinical trials 101..but it's not very ethical to make terminal brain cancer patients walk around with an unpowered helmet attached to thier head for 18 hours a day. Given the promosing early data of TTFs you would have had two choices:
1) Run an unblinded trial
2) Don't run any trial and just trash it in the garbage.

I'd go for 1 every day even though it's obviously not optimal.

You seem to be saying that because there was the potential for novocure to be biased that they were and not only that that they did it on a massive scale. Yet you have no hard evidence for that at all.

"You simply can’t handle words like unreasonably “extrapolate” or “forecast.”"

KM analysis is not a forecast either. It's simply a way of making the best of lossy data.

" Why do you think Dr. Liau would state that her, and many of her colleagues do not believe Optune works? "

When did linda liau say that?