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VuBru

12/21/20 1:47 PM

#341294 RE: HappyLibrarian #340847

Happy - I am not saying results will be a failure whitewashed to look like success. What I am saying is we will likely have success based on the new primary endpoints (which regulators seem to agree with), but possibly may have failure based in the original ITT PFS and OS endpoints (now secondary endpoints). We dom't even know that failure of the latter is the case until we know whether DCXAC worked significantly in recurrent GBM and what adjudicated PFS looks like. So I am arguing for success that will require significant explanation (beyond 22--3 paragraphs) for readers to comprehend it accurately.