Replies to post #234950 on Biotech Values

[DewDiligence]

(RVNC/ABBV)—…‘microsphere’ is almost certainly misleading. HAp tends to form acicular crystals even at micron scale. If the particles are amorphous, then might be different matter but I suspect that crystallization is on order of weeks to months. Not sure I’d want that going on in my face.

Can you elaborate on the above? I do not understand exactly what you are saying. TIA

Radiesse, a HAp product with no HAc, has a long duration of action, but it results in hard bumpy feel. That’s why almost no one uses it anymore.

p.s. Some PubMed references from Korea:
https://pubmed.ncbi.nlm.nih.gov/28865186/
https://pubmed.ncbi.nlm.nih.gov/27164868/

[dewophile]

The company website says the Ca crystals form a scaffold for "fibroblast ingrowth". So I am assuming the purpose of micronizing the particles (which could be a misnomer based on what you say) is so they don't last too long - in effect leaving collagen deposited by fibroblasts in the injected area after the scaffold is resorbed

PS: you hear about drugs that are "micronized" - usually to help gut absorption - but i wonder if the term is used pretty loosely in general