Their approach is highly modular, based on the simple and rapid combination of a mesoporous silica material, an adjuvant, the dendritic cell-recruiting factor GM-CSF, and one or more antigen(s). Many different antigens and adjuvants can be combined in a plug-and-play fashion.
In vitro and in vivo virosome uptake Human cord blood CD34+ precursor cells were cultured one week with 50?ng/mL of GM-CSF and 5?ng/mL of IL-4 (from Miltenyi Biotec) for differentiation in DCs7
30. Buchbinder, S. P. et al. Immunogenicity of a novel Clade B HIV-1 vaccine combination: results of phase 1 randomized placebo controlled trial of an HIV-1 GM-CSF-expressing DNA prime with a modified vaccinia Ankara vaccine boost in healthy HIV-1 uninfected adults. PLoS ONE 12, e0179597 (2017).
The platform, which is known as OMNIVAX and is sponsored by the BMGF, aims to reduce the per-dose price of the trivalent poliovirus vaccine from around $2 to $0.15.
More recently, Batavia has been working with Univercells and Merck to create a low-cost manufacturing platform that will significantly ease the cost of global health vaccines.
The company has state-of-the-art laboratory infrastructure in both the Netherlands and the US, and is well equipped to develop any biopharmaceutical – be it an antibody, recombinant protein or vaccine – from early discovery all the way through to clinical manufacturing.
Mymetics CorporationMyanmar Institute of Information Technology (MIIT). ??????2 ? ... Matthijs Baart. Virologist & BioRisk Officer at Batavia Biosciences.
Batavia to manufacture IAVI's replication-competant VSV for the treatment of COVID-19 infection, Marburg and Ebola virus infection International AIDS Vaccine Initiative Batavia Biosciences BV Payment unspecified 3/5/20
Batavia to manufacture and distribute Wistar's rubella vaccine seed stock RA 27/3 worldwide Batavia Biosciences BV Wistar Institute of Anatomy & Biology Payment unspecified 4/29/20