Hi iddrisw, Boreal and I also shared some thoughts about the statistics, which you can read. His approach is different but also useful. I suspect that both methods lead to similar answers. One think to ask you is if you calculated endpoint differences the same way he did, which is based on the trial protocol and he described yesterday. In other words, did your random number generator provide ranges from negative to positive as Boreal stated or can it be modified if it didn’t? This would be helpful to know if both methods are consistent.
Thanks