Replies to post #16210 on Tao Synergies Inc (TAOX)

[runncoach]

An outside variable in a disease like AD that is so poorly understood that it has a 99%+ failure rate? You don't say. Likely why we have been the only company willing to try in this population in years. If it is something relating to the microbiome that would be a huge plus for us as the crohn's data a year ago proved. Leaky BBB causes would also be a huge plus.

Check out figure 2E for any curious if bryostatin can't repair a leaky gut. If anyone has data or research of any AD drug that shows endothelial barrier repair I would love to see it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652299/

[Cyosol]

Definitely. I doubt it has anything to do with genetics or bacteria in the gut though, otherwise we'd have found a common cause in AD patients by now.

Genes and microbiomes affect the disease, sure, but they're not what's causing it. Having the APOE4 gene or a lack of certain bacteria in the gut does not guarantee someone getting AD. Something is causing those neurons to self-destruct and it needs to be something that every AD patient has.

For now I'm encouraged by the consistent improvement in moderate patients. Repairing a broken car won't keep the rust away though until you figure out how to apply anti-rust paint, and it certainly won't help if the car is falling apart faster than you can repair it.