Replies to post #10404 on Grey Matters Health Inc (AGNPF)

[AllGold818]

Algernon Pharmaceuticals could have something great.




How about an update?







(AGNPF)

[medchem]

There are a few concepts at play here:

1. Coronavirus infection is associated with a massive release of pro-inflammatory cytokines (e.g. TNF alpha and interleukins)

2. Pro-inflammatory cytokines can cause leaky vessels and lead to conditions like ARDS (lung disease)

3. NMDA receptors play a role in small blood vessel permeability

4. NMDA receptor antagonist ifenprodil can inhibit the excess glutamate related toxicity and decrease blood vessel permeability leading to less lung disease