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Re: tcm55 post# 10404

Saturday, 10/17/2020 1:48:58 PM

Saturday, October 17, 2020 1:48:58 PM

Post# of 16771
There are a few concepts at play here:

1. Coronavirus infection is associated with a massive release of pro-inflammatory cytokines (e.g. TNF alpha and interleukins)

2. Pro-inflammatory cytokines can cause leaky vessels and lead to conditions like ARDS (lung disease)

3. NMDA receptors play a role in small blood vessel permeability

4. NMDA receptor antagonist ifenprodil can inhibit the excess glutamate related toxicity and decrease blood vessel permeability leading to less lung disease

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