Replies to post #257694 on Anavex Life Sciences Corp (AVXL)

[georgejjl]

Expect PA from the TGA for PDD if p < 0.001 possibly even of p < 0.01

GOD bless,

[Investor2014]

In my view Anavex must do the stratification to discuss alongside the topline results.

Otherwise Anavex fails to use and explain their precision medicine approach and to highlight how the next trial will have high chances of success.

[boi568]

Doc,

I am interested in what factors have persuaded you to come to predicting a 20% chance of success.

Are you skeptical of the theory of Anavex's case for 2-73 across CNS diseases? (If so, why?)

Are you concerned with imprecision in trial design measurements that would hurt the p value?

Has your experience to date with so many biotech failures led you to believe this will also likely fail to achieve a p of less than .05 for the primary endpoint and the secondary sleep endpoint?

Or is it something else?

Thanks.

[boi568]

Reposting questions for Doc328. I assume they were overlooked:

Doc,

I am interested in what factors have persuaded you to come to predicting a 20% chance of success.

Are you skeptical of the theory of Anavex's case for 2-73 across CNS diseases? (If so, why?)

Are you concerned with imprecision in trial design measurements that would hurt the p value?

Has your experience to date with so many biotech failures led you to believe this will also likely fail to achieve a p of less than .05 for the primary endpoint and the secondary sleep endpoint?

Or is it something else?

Thanks.