Replies to post #257570 on Anavex Life Sciences Corp (AVXL)

[frrol]

You have doubts about the PDD trial overall, or just motor response?

[frrol]

I'd have liked MMSE to have been as measurably responsive as the ADCS-ADL. With placebo controls the baseline for the latter can shift more and net benefit might not prove out. So we'll have to see.

[blu_1]

So, 2-73 was most effective in subjects w/Apoe4, or in those lacking Apoe4?

High concentration group had higher frequency of Apoe4, so that may be why Apoe4 had the low p value, no?

[blu_1]

If the high conc group had a normal incidence of Apoe4, do you think that group probably would have scored better?

[bas2020]

I'm recalling from past presentations that ApoE4 was not a factor in the efficacy of 2-73. Several of the patients, expressing the ApoE4 gene, responded well to 2-73, at appropriate serum levels.