APOE3, found in about 70% of the population, is the most common variant and is considered neutral. APOE2 is the rarest form, found in 5-10% of people, and is associated with reduced risk of Alzheimer's. APOE4, found in 10–15% of the population
" In addition to time, APOE e4 status (P < .0001), and blarcamesine (ANAVEX2-73) mean concentration were significant predictors (Figure 2a and 2b and Supplementary Tables 4b, 4c ). Additional significant variables in this model were SIGMAR1 p.Gln2Pro, COMT p.Leu146fs, and APOE4 e4 status interactions with time."