…I don't think this will be enough and combinations are needed…
No question about that (IMO), but the salient point is that no one will want to administer PD-(L)1 agents indefinitely the way nukes are currently used to treat chronic HBV. Hence, unless PD-(L)1 agents can be a component of some kind of curative regimen, they won’t have any commercial role to play in HBV.