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jondoeuk

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jondoeuk

Re: DewDiligence post# 228365

Thursday, 01/23/2020 3:37:50 PM

Thursday, January 23, 2020 3:37:50 PM

Post# of 251706
The infection drives PD-L1 expression in hepatocytes [1]. Also, HBV-specific T-cells are enriched in the liver, so it makes sense to target the PD-1/PD-L1 axis as this should help restore T-cell function [2].

However, I don't think this will be enough and combinations are needed [3,4].

Refs:
1 https://gut.bmj.com/content/59/Suppl_2/A37.1
2 https://www.gastrojournal.org/article/S0016-5085(09)01747-8/fulltext
3 https://www.gastrojournal.org/article/S0016-5085(12)01292-9/fulltext
4 https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003208



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