Replies to post #228034 on Biotech Values

[DewDiligence]

Addendum—The insect-refuge quiz in #msg-51033222 may have been the hardest quiz I’ve ever posted on this board. I never expected it to come up in an oncology context, ten years later!

[Fred Kadiddlehopper]

That's fascinating. Thanks.

[swampboots]

One really odd thing about this "new" approach.....Seems like cave man knowledge, as killing cancer cells with drugs have started in earnest in 1940's,......... so in 80 years one might think that the limitations and benefits of this approach were known? And yet this approach might be be a basic tool investigated for every systematic cancer killing strategy to prolong the chronic treatable time table for all cancers. And yet this approach could have been discovered by a prisoner in solitary confinement, who just out of boredom requested all data regarding cancer treatments interrupted by miss appointments or sudden insurance cancellations affecting standard protocols against realized survival rates.

[DewDiligence]

Re: Resistance to combination therapy

https://www.scientificamerican.com/article/combining-multiple-antibiotics-may-make-bacteria-more-likely-to-develop-resistance/

Theoretically, the second drug in a combination is expected to kill any of the microbes left alive by the first antibiotic. But the new study demonstrated that when a patient is already tolerant to the first drug, adding a second one spurs resistance by promoting the reproduction of bacteria that were not killed immediately.

…the same evolutionary processes involved in the development of antibiotic tolerance and resistance are likely at play in cancer as well and might be used to inform treatment. Tumor cells might become tolerant of chemotherapy first and then develop resistance and spread it to other drugs.

I don’t understand the premise of this write-up, particularly how it applies to oncology; it does not seem to logically flow from the thesis discussed in #msg-153175785. Comments?