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Replies to post #206250 on Anavex Life Sciences Corp (AVXL)
In samples from healthy people, and those from people with two other degenerative brain disorders, these wake-inducing neurons survived, the researchers found. These brain diseases — progressive supranuclear palsy and corticobasal degeneration — both involve tau accumulation. But fewer neurons from people with those diseases died, despite being packed with tau, the researchers found. That unexpected finding “unveils a mystery,” Mander says. “Why are these neurons dying more in Alzheimer’s disease than in other diseases?”
The current study included samples only from people with late-stage Alzheimer’s. Grinberg is beginning a larger study of brain tissue from people at multiple stages of Alzheimer’s, in the hopes of spotting exactly when the neurons in these wake-promoting pockets start to deteriorate.
