Replies to post #194428 on Anavex Life Sciences Corp (AVXL)

[XenaLives]

Speaking of proof - can you back this up?

And let me tell you one thing vitamin B12 are a heck of a lot more safe then A273!

Do you mean efficacy?

That A273 is safe or not is just one hurdle the other is efficiency.

The relationship of sleep quality to neurogenesis is well established science. All that will be needed to prove efficacy is proof of improved sleep quality. New electronic monitoring methods will easily show this in the P2/3 population.

Since current sleep meds are dangerous and do not provide quality, theapeutic level sleep, the SOC for sleep is just as crappy as the SOC for Alzheimer's.

Just Google "increased rem sleep neurogenesis":

Most methods of sleep deprivation that have been employed affect both non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. ... However, a number of studies clearly show that prolonged sleep loss can inhibit hippocampal neurogenesis independent of adrenal stress hormones.Oct 9, 2008

New neurons in the adult brain: The role of sleep and consequences ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771197/
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Modulation of Adult Hippocampal Neurogenesis by Sleep: Impact on ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643465/
by C Navarro-Sanchis - ?2017 - ?Cited by 5 - ?Related articles
Oct 12, 2017 - Rats subjected to 7-day sleep fragmentation also showed less suppression of REM sleep (presumably due to an increased homeostatic drive ...
?Modulation of adult ... · ?Effect of sleep on adult ... · ?Bridging the gap: effects of ...

New neurons in the adult brain: The role of sleep and consequences ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771197/
by P Meerlo - ?2009 - ?Cited by 262 - ?Related articles
Oct 9, 2008 - Most methods of sleep deprivation that have been employed affect both non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. ... However, a number of studies clearly show that prolonged sleep loss can inhibit hippocampal neurogenesis independent of adrenal stress hormones.
?Abstract · ?Effects of sleep deprivation ... · ?Sleep deprivation, learning ...

Sleep and adult neurogenesis: implications for cognition and mood.
https://www.ncbi.nlm.nih.gov/pubmed/24218292
by AD Mueller - ?2015 - ?Cited by 35 - ?Related articles
There is modest evidence that periods of increased sleep are associated with ... of sleep exceeding 24 h, by total deprivation, selective REM sleep deprivation, ...

Rapid Eye Movement Sleep Deprivation Contributes to Reduction of ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225569/
by R Guzman-Marin - ?2008 - ?Cited by 100 - ?Related articles
Revealing the relative impact of REM and NREM sleep on neurogenesis is a ... Agreement of manual and automated REM detection was greater than 95%.
?Abstract · ?MATERIALS AND METHODS · ?RESULTS · ?DISCUSSION

Detrimental role of prolonged sleep deprivation on adult neurogenesis
https://www.frontiersin.org/articles/125212
by C Fernandes - ?2015 - ?Cited by 25 - ?Related articles
Recently, an influence of sleep in adult neurogenesis has been established, mainly ... cyclically repeated: the rapid eye movement sleep (REMS) and non-REM ...

Memory consolidation during sleep and adult hippocampal ...
www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue...
by I Koyanagi - ?2019 - ?Cited by 2 - ?Related articles
Nov 21, 2018 - Keywords: rapid eye movement sleep; sleep deprivation; .... longer periods of sleep deprivation causing greater impairments in neurogenesis.

Sleep deprivation can inhibit adult hippocampal neurogenesis ...
https://www.physiology.org/doi/abs/10.1152/ajpregu.00858.2007
by AD Mueller - ?2008 - ?Cited by 112 - ?Related articles
Sleep deprivation (SD) can suppress cell proliferation in the hippocampal dentate ... REM sleep loss increases brain excitability: Role of noradrenalin and its ...

Concise Review: Regulatory Influence of Sleep and Epigenetics on ...
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.2815
by KG Akers - ?2018 - ?Cited by 4 - ?Related articles
Jump to Role of Sleep in Epigenetic Regulation of Adult DG Neurogenesis - REM sleep is characterized by ... adult DG neurogenesis by controlling the timing of cell cycle events 37. ... show decreased hippocampal mRNA levels ...

Sleep deprivation inhibits adult neurogenesis in the hippocampus by ...
https://www.pnas.org/content/103/50/19170
by C Mirescu - ?2006 - ?Cited by 211 - ?Related articles
Dec 12, 2006 - Prolonged sleep deprivation is stressful and has been associated with ... elimination of time spent in rapid-eye-movement sleep (REM).

Adult Neurogenesis: Regulation By Sleep - Dennis McGinty - Grantome
grantome.com/grant/NIH/I01-BX000797-01A1
By manipulating NREM and REM sleep, we will determine what properties and stages of ... DG GABA release is increased during consolidated sleep, and sleep ...