The Johns Hopkins article’s conclusion definitely suggests that once results come in, assuming they validate these results, that the Standard of Care would necessarily need to adapt to include DC Vaccines into the Standard of Care, with some further understanding of relevant details for facilitating that integration.
“Conclusions
DCs play a critical role in bridging the innate and adaptive immune system and have a complex range of functions and phenotypes in the GBM TME. Preclinical and clinical studies have demonstrated measurable immunological response and variably prolonged survival rates. Various combinations of synergistic adjuvants aimed at overcoming the diverse glioma-induced immunosuppression have shown promise. The interim report from the first Phase III trial of DCV in newly diagnosed GBM confirms safety and feasibility and suggests longer than expected survival with DCV. While we eagerly await the final results from the study and results from other Phase III studies, there is need to further explore the optimal combination of immune-based therapies, ideal integration of these therapies into the current standard of care, and responder phenotypes to identify patients who are most likely to benefit from the therapy. Continued increase in understanding of the immunogenomics of GBM and pathways of tumor evasion will allow for refinement of DC-based immunotherapy and development of patient-specific tumor treatments.”
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