ANAVEX 2-73 Normalizes Hippocampal BDNF Expression p<0.05 § Administration of ANAVEX 2-73 in the Fragile X Fmr1 KO mouse significantly restores hippocampal BDNF expression to the same levels observed in vehicle-treated wild- type mice (p<0.05, KO vehicle vs. KO ANAVEX 2-73)
A more recent study by a division of NIH on the roles of Sig-1Rs;
Thus, the Sig-1R plays a role in the mediation of many cellular functions, making it a protein of great interest for treatments of neurological disorders.