Replies to post #7371 on Rebus Holdings Inc (RBSH)

[eric1x3]

Good question. Anyone?

(I own shares but curious.)

[Goodmooring]

This is my biggest guess as to why the stock fell.

None of this info was released by INSPYR. But all these publications mention INSPYR or a combination of Mipsagargin and Thapsigargin.
Both Mipsagargin and Thapsigargin are Patented until 2034 by INSPYR Therapeutics!!


Found a reason for being dark, progress is being made though...
They couldnt make enough of the drug to enter Phase 3 clinic trials.
Dec 2018 break through


August 2016 - Phyton Biotech Achieves Manufacturing Milestone with Thapsigargin, the Active Agent in Mipsagargin

May 2017 - Inspyr Therapeutics is believed to be close to starting Phase III human trials of mipsagargin. For future trials, companies may need a metric ton per year of thapsigargin, Christensen says. Isolating that amount of product from plants is not currently feasible, engineering organisms to make thapsigargin isn’t possible because the biosynthetic pathway is not fully known, and the semisynthesis of the compound in large amounts from a readily available natural product is possible but unproven.
With 42 steps and less than 1% yield, that synthesis isn’t practical for making large amounts.
https://cen.acs.org/articles/95/i19/Improved-routes-thapsigargin.html

Until:
Dec 2018 - Conclusions: Shoot regeneration, rooting and biomass growth from leaf explants of T. garganica were achieved, together with a high yield in vitro production of thapsigargin in TIBs.
https://www.researchgate.net/publication/327536730_Use_of_a_temporary_immersion_bioreactor_system_for_the_sustainable_production_of_thapsigargin_in_shoot_cultures_of_Thapsia_garganica
Replies:
WOW....all I can say is WOW!
Insider99 on 2/21/2019 9:45:58 PM
So what does this mean?
RiverNorth0x on 2/21/2019 10:01:13 PM
Great work. This weekend I had planned to
empiricalONE on 2/22/2019 4:49:32 AM
Love your post Goodmooring:
Baxy on 2/22/2019 12:29:48 PM



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[Goodmooring]

Forgot to add this to the timeline

https://www.queensu.ca/gazette/stories/new-hope-cancer-patients

Previously took 42 steps this article shows they found a way to do it in 12 steps..

“The team of P. Andrew Evans (Chemistry) and his graduate student Dezhi Chen developed an efficient route to thapsigargin in only 12 steps.”

[empiricalONE]

Phase 2 took 100mil in financing, they covered part of that by selling shares, which drove the price down. I watch for companies to do this. When the price bottoms, there is nowhere to go but up, that's when I buy stocks like this. NSPX is massively undervalued right now, and the price correction will be significant. Just a waiting game at this point. It's a good time to be a new shareholder here.