Replies to post #182758 on Anavex Life Sciences Corp (AVXL)

[Investor2014]

Dr. Bredesen imo is one those just a too fast talking public docs with a good story - but perhaps should not be discounted.

Anyway he raises my sceptic instinct.

[nidan7500]

In summary, a targeted, personalized, precision medicine approach that addresses the multiple potential contributors to cognitive decline for each patient shows promise for the treatment of Alzheimer’s disease and its harbingers, MCI and SCI. The improvements documented in the 100 patients reported here provide support for the performance of a prospective, randomized, controlled clinical trial, especially given the current lack of effective treatment for this common and otherwise terminal illness.

Makes perfect sense and does not contradict/conflict w/Homeostasis thinking. One size does not fit all. Biomarkers matter. The dark period of Amyloid thesis if finally over.

[falconer66a]

Probably Works; But Is Unworkable

Yes, some really fine therapeutic outcomes. Mental health of Alzheimer's patients wonderfully improved.

But, it was accomplished not with a drug but by an extremely detailed and complicated health "protocol." Simply, the therapists treated just a zillion health problems, and cognition improved.

Would (or could) you administer to Aunt Matilda all of the following when she started for forget stuff?

Here's stuff done and taken:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221920/#!po=34.0909

Optimize diet: minimize simple CHO, minimize inflammation.
Patients given choice of several low glycemic, low inflammatory, low grain diets.
Minimize inflammation, minimize insulin resistance.
Enhance autophagy, ketogenesis
Fast 12 hr each night, including 3 hr prior to bedtime.
Reduce insulin levels, reduce Aß.
Reduce stress; Personalized—yoga or meditation or music, etc.
Reduction of cortisol, CRF, stress axis.
Optimize sleep; 8 hr sleep per night; melatonin 0.5mg po qhs; Trp 500mg po 3x/wk if awakening. Exclude sleep apnea.
Exercise; 30-60' per day, 4-6 days/wk
Brain stimulation
Homocysteine <7
Me-B12, MTHF, P5P; TMG if necessary
[40]
Serum B12 >500
Me-B12
[41]
CRP <1.0; A/G >1.5
Anti-inflammatory diet; curcumin; DHA/EPA; optimize hygiene
Critical role of inflammation in AD
Fasting insulin <7; HgbA1c <5.5
Diet as above
Type II diabetes-AD relationship
Hormone balance
Optimize fT3, fT4, E2, T, progesterone, pregnenolone, cortisol
[5, 42]
GI health
Repair if needed; prebiotics and probiotics
Avoid inflammation, autoimmunity
Reduction of A-beta
Curcumin, Ashwagandha
43-45
Cognitive enhancement
Bacopa monniera, MgT
[46, 47]
25OH-D3 = 50-100ng/ml
Vitamins D3, K2
[48]
Increase NGF
H. erinaceus or ALCAR
[49, 50]
Provide synaptic structural components
Citicoline, DHA
[51].
Optimize antioxidants
Mixed tocopherols and tocotrienols, Se, blueberries, NAC, ascorbate, a-lipoic acid
[52]
Optimize Zn:fCu ratio
Depends on values obtained
[53]
Ensure nocturnal oxygenation
Exclude or treat sleep apnea
[54]
Optimize mitochondrial function
CoQ or ubiquinol, a-lipoic acid, PQQ, NAC, ALCAR, Se, Zn, resveratrol, ascorbate, thiamine
[55]
Increase focus
Pantothenic acid
Acetylcholine synthesis requirement
Increase SirT1 function
Resveratrol
[32]
Exclude heavy metal toxicity
Evaluate Hg, Pb, Cd; chelate if indicated
CNS effects of heavy metals
MCT effects
Coconut oil or Axona

[XenaLives]

It seems to be a post hoc analysis. Only those who improved are included.

Proves nothing because we don't know if diagnosis was accurate to begin with.

"MCI, and early Alzheimer’s disease "

My knees hurt today, my cognition sucked.

If I get better tomorrow because my knees don't hurt and I take an asprin is the asprin a "cure" for my cognitive decline?

(Table 1) lists 100 patients with cognitive decline due to Alzheimer’s
disease, pre-Alzheimer’s conditions MCI (Mild Cognitive Impairment)
or SCI (Subjective Cognitive Impairment), or cognitive decline
without definitive diagnosis, all of whom demonstrated documented
improvement using the same targeted, multi-component program used
for the three patients described above