Replies to post #214057 on NorthWest Biotherapeutics Inc (NWBO)

[Lykiri]

Longfellow95,

I don't know if these subjects received Bev because that caps survival after recurrence at 9 or 10 months...

Bevacizumab? (Avastin) : imo they received Bev. See this:https://pbs.twimg.com/media/DzIw-UjWoAAUuAf.jpg

More info:UCLA Health

For recurrent glioblastoma, immunotherapy before surgery appears to help more than afterward.

UCLA-led research could be step toward new therapy for hard-to-treat brain cancer
02/11/2019
https://www.uclahealth.org/for-recurrent-glioblastoma-immunotherapy-before-surgery-appears-to-help-more-than-afterward

“This isn’t a very big study, and our data need to be replicated, but we have a foot in the door,” Cloughesy said. “We have found a way to use these checkpoint inhibitors in glioblastoma that we previously thought were ineffective. We now have a rational and logical way to develop immunotherapies going forward and a clinical development process for doing it.”

The team is now testing the immunotherapy in combination with vaccines and other checkpoint inhibitors.

And this:

Article | Published: 11 February 2019
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma
https://www.nature.com/articles/s41591-018-0337-7