Replies to post #176119 on Anavex Life Sciences Corp (AVXL)

[Talon38]

Steady.....along those same lines. Look especially at the last paragraph of this article.

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https://www.fiercebiotech.com/research/how-neurons-fend-off-alzheimer-s-a-cellular-broom-clears-toxic-tau-protein?mkt_tok=eyJpIjoiWVdOa05ESTRORGhtWXpZeCIsInQiOiJ4UWxVM3kzZ3dCVmx6TjNJWlorK25DXC8yUFdyXC9NMk1laHJJV094c3o1cFZEcGR1aEFmUEhhQ0J4QjlBWHlDXC93KzNFV250enFKdU5hWmw2eFdyRkMxTlhDUFlsZnU3SjNwZmJTMmFsTnNwYzhVRHlJNTM2MUN1UEE2RkJMaXg0TyJ9&mrkid=6254940&utm_medium=nl&utm_source=internal

[nidan7500]

A Fleming moment?:

It all started when Sergei Baranov, Ph.D., a staff scientist in Friedlander's lab, noticed an interesting phenomenon in mouse nerve cells that he was growing in the lab.

"Their mitochondria, the cellular powerhouses, weren't working as well at the neurite ends" said Baranov. Then, when the researchers looked at neurons in the spinal cords of mice, they found the same phenomenon. "Other researchers must have noticed this as well, but we were able to visualize it and suggest the potential cause as well as outcome," he noted.

The researchers found that when proteins in mitochondria at the ends of neurites were damaged by normal wear and tear, newer ones weren't coming in to replace them as quickly as they did for mitochondria near the nucleus. This made them function less efficiently, which activated 'executioner' enzymes called caspases and ultimately led to neurites withering away.

Thanks for posting, great catch.