Replies to post #204858 on NorthWest Biotherapeutics Inc (NWBO)

[marzan]

John, good find! Thanks!! interesting to note the following from L's own words:

(“pseudoprogression”) for possibly 6 months before it gets smaller.

Then, how could one conclusively assess PFS in GBM Immunotherapy, I mean DcVax L as there are no ther immunotherapy GBM trials survive as we speak. As Doc consistently says Adjudication is the only resort here and can be done only after Unblinding, imo. Whoever wants to see PFS number before Adjudication don't have real interest in this therapy, imo.

[Know-Fear]

Also point out IU is one of the PIII trial sites. Intersting they'd bring Dr. Liau in at this juncture.

[flipper44]

There you have it.

After injections of these drugs, a tumor may enlarge (“pseudoprogression”) for possibly 6 months before it gets smaller. -- Dr. Liau, December 2018.

That is a real share from Dr. Liau, given the timing of her statement.

[Lykiri]

john1045,

good find! Thanks!! I like the title!!!

IN THE NEWS
Campbell Lecturer Details New Directions in Brain Cancer Treatment
December 20, 2018 | Goodman Campbell | Brain Health, Events

Liau also described one of the main challenges is measuring whether an immunotherapy drug is working against a glioblastoma tumor. After injections of these drugs, a tumor may enlarge (“pseudoprogression”) for possibly 6 months before it gets smaller.
Therefore, standard imaging techniques, such as MRI, to assess whether tumors are growing or shrinking in response to treatment are not as sufficient in brain cancer.
https://www.goodmancampbell.com/in-the-news/campbell-lecturer-details-new-directions-in-brain-cancer-treatment

Here is an example of that "wait and see".

July 30, 2015 at 1:17 pm
Report
My dad is in the DC Vax L trial and just started the cross over arm about 2 weeks ago. He's received 2 injections so far and 1 next week since he's been in the cross over arm.

He started the trial around a year ago and was crossed over 2 weeks ago due to progression. At first Drs thought it was scar tissue but after 3 mris (6 month time frame), it became more clear it was slow tumor growth.

Source: Inspire.com

Merry Christmas!