Replies to post #175327 on Anavex Life Sciences Corp (AVXL)

[nidan7500]

Biostock, again thanks for the amazing work and effort to support us here. Can you close the loop around A2-73 and the concept of restoration of CNS cellular homeostasis for me. I understand it must be right on the tip of your thoughts. That concept has me hooked on this company. TIA. Is that where this all ends up?

[falconer66a]

Again, A Vitamin D Factor?

...the countries where AD is broken out by gender and men have the highest incidence (not higher than women but highest in the world) are Muslim countries

I believe the implication here is that in Muslim countries women have higher rates of Alzheimer’s.

If so, might the sun-screening garb of Muslim women play a part, should the occurrence of Alzheimer’s or other senile dementias be somewhat controlled by adequate vitamin D levels (as shown in the paper below)?

Cholecalciferol, the essential precursor to Vitamin D, is photosynthesized in skin, by rather direct, intense ultraviolet B spectra from sunshine. Cover the skin, and vitamin D synthesis is prevented, chronic inadequacies result.

This peer-reviewed paper made this conclusion:

Low VitD status was associated with accelerated decline in cognitive function domains in ethnically diverse older adults, including African American and Hispanic individuals who exhibited a high prevalence of VitD insufficiency or deficiency.

https://jamanetwork.com/journals/jamaneurology/fullarticle/2436596

I'm taking 7500 IU of vitamin D-3 each day, now with a serum level of around 80ng/ml. In my early seventies I've retained and utilize the mental capacities I had in my thirties. Have been popping vitamin D since the turn of the century. Adequate vitamin D supplementation has been productive.