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TastyTheElf

11/01/18 11:56 AM

#153856 RE: Biobillionair #153845

No, BB, it was probably powered at around 50% to detect it at a 20ish% assumes RRR.

I can crunch that at 300 CV deaths later...
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rfj1862

11/01/18 3:14 PM

#153915 RE: Biobillionair #153845

No it wasn't--the power calculation is made for the primary end point.

It doesn't mean that it couldn't be significant...but all of the end points above it in the hierarchy would need to also be significant.

I'm sure you guys have already discussed this here ad nauseum but the statisticians literally go down the list, and as soon as they hit an end point that is not significant, every end point after that is also not significant.

We'll see how far they make it down the end point list! I'm hoping for all the way.