Replies to post #169538 on Anavex Life Sciences Corp (AVXL)

[LakeshoreLeo1953]

Dad....

I will continue to relish your input.

Being the financial and not scientific investor
I am not sure that anything other than a "homerun"
will drive pps.

Hopeful, but hoping current -$11K is mitigated
by my year end limitation.

Locking in gains NVDA, AMD, and others was lucky, but beneficial.

[tradeherpete]

Biostockclub and Dadofmarcmax, thank you.

Dado, that should be published as is.

In the opinion of this igorant trader. ;)

[kevindenver]

Thank you for posting.
As a cannabis educator and advocate, I have been seeking a "unified theory" as to why differing types of disease states and ailments all seem to intersect with the endocannabinoid system.

My personal testimony to better health has been modifying my diet and supplementing my endocannabinoid system with amazing success.

Thank you again. Especially for including your sources!

Curious do you or your partners plan on publishing?

[Investor2014]

Dad, very readable and to me very interesting review. I find your perspective of a systems biological explanation for many ‘modern’ diseases and the accelerating predominance of them logical.

As an engineer not trained in biology and medicine I can still appreciate how complex a biological system can evolve to be over billions of years.

All we have to do is to follow the trail of health destruction that comes to populations as they become ‘fortunate’ enough to be able to adopt a more western lifestyle and diet.

I have a daughter studying medicine having started with a biomedical sciences undergrad partly because I have encouraged that and mostly because she is scientifically inclined with her own appetite for figuring out how stuff works and with the idealism of youth.

My hope and expectation is that she, through her appreciation of science and the scientific method, will retain the curiosity as a medical doctor that you show and retain her critical thinking approach. Although I appreciate the busy life and responsibilities of a doctor can easily result in following the book and the friendly BP sales representative.

Keep curious and critical and thank you for sharing your insights and perspectives.

[Cbdpotential]

Too little too late
Imo
I'm ashamed for the medical community
Pot
Marijuana
Weed
- ?!
It's cannabis
And the endocannabinoid system has been ignored for decades

Why? Why have minds changed?

Oh ya .. Money ... and the medical communities extreme lack of courage..
Shameful at best

.. Reminds me of ex DEA agents opening dispensaries ..

[FightingIrish82]

As a chiropractor , I say welcome aboard upon your new health perspective and in your efforts to rebuild your new practice. Pertaining to CB1/CB2 and related info, I am a firm believer in the focus on health, diet included. Not saying it cures all or that anyone has all the answers, but to say the least its a good first step to avoid the Rx and Sx at all cost for most people.

The perspective of evolution begs me to think that the new normal is where it is at. Adaption is key without it and death certain. Between gut changes compared to our ancestors to micro plastics being found in everyone's gut, I find it confusing to say the least. Who's gut would be better to adapt to today's world or even the next million years ?

Up regulation is good the simpler the better!

Thanks for the read!

[nidan7500]

dadofmarcmax:

Complicated disorders cannot simply fit into simplistic models – made just so that people can understand them better. The genetic component of all complex traits, such as hypertension, arthritis, and cognitive function, is influenced by a broad range of effects spread across many single nucleotide polymorphisms in many genes (Cooper RS. 2003. "Disease as Multifactorial" Ann Intern Med 139:437-40). Thinking of chronic diseases as being related to multifactorial etiologies makes much more sense than thinking from the simplistic paradigm that diseases are caused by only one specific and isolated pathophysiological process. Complicated neurological disorders must be viewed as a whole – a systems problem, a network biological problem. Network biology theory predicts that modulating multiple nodes simultaneously is often required for modifying phenotypes. When thinking about pathophysiology affecting networks, the usual mathematical techniques of linear approximation-linear regression, normal coordinates, mean field approaches, and the like - make little progress in the analysis of complex adaptive systems. This seems to be why simplistic approaches to “solve” neurodegenerative disorders like Alzheimers disease (through the clearance of beta-amyloid plaques) have only led to failures. Perhaps, taking this “big picture” approach to neurological disorders is the paradigm that scientists must now think within as it will then help to understand that complicated network problems may actually be related to more simplistic overall dysfunction of a common connected system. It becomes clearer now to see health dysfunction as being related to dysregulation of homeostatic mechanisms and seemingly unrelated disorders now seem related when you think of these disorders from this perspective.


The allowance of the body to “heal itself” has been the antithesis of what allopathic medicine is. Allopathic medicine teaches us that there is a pharmaceutical and/or surgical fix to a problem and therapeutics have always developed from this basic “rule.” Now the concept of “restoring cellular homeostasis” is allowing for more insight into thinking about diseases from the systems biology standpoint and new pharmaceutical approaches can now be made to enhance the body’s natural ability to heal itself.

Great thoughts, thanks.