Nice link thanks.
Naturally, with better models better outcomes. They are the earliest predictors of success we need the greatest accuracy in order to get close to actual remedies to diseases.
The cellular grown brains are to the mouse models what computers are to calculators. There is so much more we can incorporate which is actually in the human brain which will respond accordingly if done correctly. When we throw stuff or alter animals as hoc the responses should not really be expected to address real life because no model comes down on all fours.
But, the grown ones all the potential to wire things up differently without being attached to a completely separate life support system in other living things - so they are not so much altered as created as more exact models.
So much potential - and quick, less expensive, greater outcomes...
We are making leaps. Great article!