Replies to post #160927 on Anavex Life Sciences Corp (AVXL)

[OFP]

Anything is possible, but it is unlikely and unexpected that a group of Alzheimers patients selected for both wild-type Sigmar1 AND COMT genes would normally see their average scores for BOTH mmse and adsc-adl improve after 57 weeks.

Actually it's entirely expected that after one year the top quartile would have positive values for any placebo group...after all the data slicing and dicing that is all that is left. They started with 32 and the final group to get the PR's "positive" finding likely relies upon 7-9 patients.

As SteadyT points out...you can do the post hoc steps for hypothesis generation. It's entirely reasonable if that is your purpose with the intent to rigorously test it.

However, I will point out that when you start PR'ing this with p values attached you are going to mislead a lot of people. As many comments today illustrate.