Replies to post #183471 on NorthWest Biotherapeutics Inc (NWBO)

[Pablosrv]

Ok nothing new then, apart from her obvious disgust to not unblinding.

[JRIII]

Wait, you mean Linda Liau confirmed what I have been saying all along? That the SAB is just a distraction? Yeah, that's what I thought.

When asked about the DCVax trial she states that unfortunately the unblinding is up to the corporate sponsor, not investigators.

[flipper44]

Just prior she talks about pharmaceutical companies unblinding too early, then, once talking about DCVax, she talks about wanting know who is who once the trial is unblinded. Do you think she thinks the DCVax trial has put the time in? They are certainly way beyond the time pharmaceutical companies normally go. Why does she keep doing these informal conferences and interviews that preempt official releases? Typically making many assume the worst for the trial? Only a small percentage of people even knows this occurred.

[survivor1x]

With respect to the median.

She was talking in general about the limitations of clinical trials up to date in cancer. What the Oncology field as a whole now understands that just because you have melanoma it may not be the same as another patients melanoma yet clinical trials to date measure the groups of patients as a whole that may give signals of reduced efficacy because of non responders (If it only works in 30% of patients it's past the median). She also states that some companies may be unwilling to only work on just these subgroups because they then can only sell a drug to these subgroups. So it can pose a challenge. Note she was not speaking about DC VAX, just cancer treatments in general. DC VAX was a follow up question and she said it's out of her control as far as un-blinding, she didn't want to comment any further because the trial was still ongoing but was looking forward to unblinding so she can learn from both repsonders and non-responders.

As far a combo treatments she was saying that cancer finds a way to come back or adapt to 1 treatment so to hit a cancer after its been weekend by 1 treatment with another.

I did not hear anything in this interview that would give me pause with respect to the DC VAX trial. Most of this was high level general information.