Replies to post #148014 on Anavex Life Sciences Corp (AVXL)

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Probably this:


Juvenile Toxicology: Relevance and Challenges for Toxicologists and Pathologists


“Juvenile toxicity studies involve a large number of animals, numerous and diverse study endpoints, and often multiple cohorts of animals in order to adequately address these endpoints. Factors such as latency of effects, litter effect (best controlled with a cross-fostering method), dosing of pups as young as postnatal day (PND) 1, pooled blood collections, dosing adjustments based on daily body weights due to rapid growth rate, and pharmacokinetic and pharmacodynamic differences in young animals must all be considered and handled with appropriate scientific and technical expertise and resources. With the many factors involved, it is difficult to have a standardized juvenile toxicity study design; thus, each study must be designed and performed on a case-by-case basis.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670269/#!po=21.1111