Replies to post #206668 on Innovation Pharmaceuticals Inc (IPIX)

[BIzzy]

batting .350 makes you millions and a place in the Hall of Fame....take that all day, everyday

[TheDane]

Your baseball analogy is good, but even a 350 hitter will smack one out every so often. I get you don’t want to overdo expectations and appreciate your sobering comments regarding results. There little worse than overwrought expectations being dashed.

I still think an argument can be made this stock should be closer to $2.00 pre-results. That could still happen, I suppose.

[scottsmith]

Thank you for the Prurisol realism. I will take a hit by pitch for that particular ipix compound.

[BioTechMaven]

Agreed on that. Folks have picked up on how when IPIX is jazzed on something, boy do you hear about it! That we’ve been hearing about Brilacidin for IBD and Brilacidin for OM, tells me it’s not bullshit, and they have something stacking up. I am very keen for a Kevetrin update, as positive MOA dileneation and demonstrates clinical benefit in the trial now should spell lucrative early deals, as oncology is the money train of the world. Pharmas thrown big bucks at oncology all day long. And the p53 holy grail is prized. Prurisol, agree again. Since there is only one approved oral for Psoriasis in the world AND it really isn’t that good of a drug, there’s room for more treatments especially safe ones. Why not try taking Prurisol and Otezla at THE same time. People mentioned pruritis—stop the itch, sufferers will line up. It’s a big space and room for different treatments. Prurisol May not beat Otezla on pasi but maybe crushes it in other important categories. Time will tell,
Hoping it does crush it in all. In mean time, OM obsessed and always watching for a partnership which would validate and transform the Rodney danger field of pharmas over night. Good luck to all and pray for us down here in CA.

[To infinity and beyond!]

agreed of course that leo's general policy of not being shy to release good news makes prurisol silence tough to take..So:

he is quiet because he decided interim data release really was against trial protocol

or, he is quiet because the trial is not a success

woulda been nice for him to explain why he dropped the planned interim release.

[petemantx]

My take is that a Prurisol deal puts IPIX in a whole new ballgame. Maybe that is why Leo has changed his modus operandi, he doesn't want to screw up a deal by talking too much? At least that is another possibility compared to thinking it is based on not quite stellar results.

[PlentyParanoid]

BioHedge, I think Leo does not have any early read about prurisol trial, simply because:
From clinicaltrials.gov: This study is designed as a randomized, double blind, parallel group, placebo-controlled trial to study the efficacy and safety of two oral doses of Prurisol administered twice daily for twelve weeks to subjects with moderate to severe chronic plaque psoriasis.

If the trial completed by Nov. 30 (as they say) and was unblinded after that (as rules say) then Leo has nothing, yet.

I have elsewhere already conceded to one mistake about Prurisol so I am stating this carefully:

Indications are that Prurisol's performance is at least equal to Regeneron's dubilumab and that for an oral medication should be enough for approval. Caveat being the results so far are from really small trial with somewhat murky history. Hence, my gut feeling is that prurisol PASI 75 will exceed 25 %. But by how much? I dunno, and I am not going to even guess.

[F1ash]

But my experience has been that Leo has never been known to play his cards close to the vest. The fact that he hasn't been dropping hints about Prurisol tells me a lot about how the trail is going . Not that it's been a bust but it's certainly not a homerun (again just my opinion).

I like the poker analogy. Historically LE has indeed been a “fast player”. Showing the other players that his hand was strong, trying to force the early fold from shorts.

Typically once a pattern is established one can use it to garner fairly reliable hints about which cards are being held by that player. However, that’s also where one can get in a lot of trouble, if a player breaks their tendency and “slow plays” a strong hand it can definitely cause a dramatic swing in chip stacks.

It would be fantastic if that is the case here. Realistically Prurisol is indeed the wild card. Mouse data was fantastic, 2A data hopeful but inconclusive, Management even labeled it their “riskiest” drug.

Not long to wait now. Got the popcorn ready for B-OM in the interim. :-)