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Re: BioHedge post# 206668

Thursday, 12/07/2017 12:17:27 PM

Thursday, December 07, 2017 12:17:27 PM

Post# of 402700
BioHedge, I think Leo does not have any early read about prurisol trial, simply because:
From clinicaltrials.gov: This study is designed as a randomized, double blind, parallel group, placebo-controlled trial to study the efficacy and safety of two oral doses of Prurisol administered twice daily for twelve weeks to subjects with moderate to severe chronic plaque psoriasis.

If the trial completed by Nov. 30 (as they say) and was unblinded after that (as rules say) then Leo has nothing, yet.

I have elsewhere already conceded to one mistake about Prurisol so I am stating this carefully:

Indications are that Prurisol's performance is at least equal to Regeneron's dubilumab and that for an oral medication should be enough for approval. Caveat being the results so far are from really small trial with somewhat murky history. Hence, my gut feeling is that prurisol PASI 75 will exceed 25 %. But by how much? I dunno, and I am not going to even guess.
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