“Although the MMSE is valid during a 1-month interval, suggesting that repeated observations over time are not confounded by a practice effect, our analysis of data collected during an observation period of up to 6 years indicated that, because of high measurement error and wide variability in individual rates of change, the MMSE had limited value as a method to mark cognitive changes in individuals with AD who are followed up for less than 3 years. Even after 4 years of follow-up, 15.8% of the remaining 82 patients had no clinically meaningful decline in MMSE score.
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