Replies to post #132914 on NorthWest Biotherapeutics Inc (NWBO)

[sentiment_stocks]

Even though the results are hopefully very clear by now, there is clearly a tension between unblinding asap and letting the trial run as long as possible to maximize demonstration of OS effect, and possibly even mPFS.

Some may want to think about the medians as they apply to the sub groups as well - for both PFS and OS.

Let's say they are seeing impressive medians in both endpoints for the mesenchymal subgroup - and that group may range between 30 to 50% of these patients (no small number).

But what if there are also other sub groups - that are not currently demonstrating as high a median - and that may be found in the 100 still alive - as well as in the 83 that had not even evented by February 2017...

... and by waiting just a bit longer, the endpoint medians for those subgroups are also raised?

[HappyLibrarian]

You may be right and we'll see "soon" enough.

[Rootjim]

kabunushi Investors frustration with an in toilet stock price,should not lead to wild lashing at management. Perhaps you understand better than others what is really going on. So your comfortable with what is going on with NWBO. Management for NWBO represent many parties for many purposes. With all the goings on with NWBO the shareholders can be easily be forgotten. The only way for them not to be forgotten is to speak up. Also the shareholders would like their fortunes to be aligned with management. Shareholders do not like to get thrown under the bus. So hopefully things will smooth out, for some smooth sailing.

[Virgilio]

there is clearly a tension between unblinding asap and letting the trial run as long as possible to maximize demonstration of OS effect, and possibly even mPFS

It's not a matter of tension, it's a matter of the co. which IMO should step in and let investors/shareholders/scientific community explain what are they doing with the trial and why.